Central Administration of BIBP3226, Neuropeptide Y (NPY) Y1 Receptor Antagonist, does not Inhibit Fasting- and NPY-Induced Food Intake in Neonatal Chicks

Abstract

Neuropeptide Y (NPY) is known to be an essential orexigenic signal in mammalian and avian brain. Since NPY receptors in the avian brain have not been clarified, to determine whether Y1 receptor or Y1-like receptor(s) mediates the orexigenic effect of NPY in neonatal chicks was examined by using BIBP3226, a selective nonpeptide Y1 receptor antagonist for mammals. Central administration of BIBP3226 (5 or 10μg) did not alter fasting-induced food intake in Experiment 1. In the second experiment, when BIBP3226 (5μg) and NPY (0.5μg) were co-administrated, BIBP3226 did not abolish NPY-induced food intake. These results suggest that Y1- or Y1-like receptor(s) do not play a significant role in regulating food intake of the neonatal chick.

Keywords

• neuropeptide y
• y1 receptor subtype
• bibp3226
• food intake
• chick