Frontiers in Neurology (Mar 2021)
Exploring How Low Oxygen Post Conditioning Improves Stroke-Induced Cognitive Impairment: A Consideration of Amyloid-Beta Loading and Other Mechanisms
- Zidan Zhao,
- Zidan Zhao,
- Zidan Zhao,
- Rebecca J. Hood,
- Rebecca J. Hood,
- Rebecca J. Hood,
- Lin Kooi Ong,
- Lin Kooi Ong,
- Lin Kooi Ong,
- Lin Kooi Ong,
- Lin Kooi Ong,
- Giovanni Pietrogrande,
- Giovanni Pietrogrande,
- Giovanni Pietrogrande,
- Sonia Sanchez Bezanilla,
- Sonia Sanchez Bezanilla,
- Sonia Sanchez Bezanilla,
- Kirby E. Warren,
- Kirby E. Warren,
- Kirby E. Warren,
- Marina Ilicic,
- Marina Ilicic,
- Marina Ilicic,
- Murielle G. Kluge,
- Murielle G. Kluge,
- Murielle G. Kluge,
- Clifford TeBay,
- Clifford TeBay,
- Clifford TeBay,
- Ole P. Ottersen,
- Ole P. Ottersen,
- Sarah J. Johnson,
- Sarah J. Johnson,
- Michael Nilsson,
- Michael Nilsson,
- Michael Nilsson,
- Michael Nilsson,
- Frederick R. Walker,
- Frederick R. Walker,
- Frederick R. Walker,
- Frederick R. Walker,
- Frederick R. Walker
Affiliations
- Zidan Zhao
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Zidan Zhao
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Zidan Zhao
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Rebecca J. Hood
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Rebecca J. Hood
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Rebecca J. Hood
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Lin Kooi Ong
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Lin Kooi Ong
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Lin Kooi Ong
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Lin Kooi Ong
- National Health and Medical Research Council Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, Heidelberg, VIC, Australia
- Lin Kooi Ong
- School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia
- Giovanni Pietrogrande
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Giovanni Pietrogrande
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Giovanni Pietrogrande
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Sonia Sanchez Bezanilla
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Sonia Sanchez Bezanilla
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Sonia Sanchez Bezanilla
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Kirby E. Warren
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Kirby E. Warren
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Kirby E. Warren
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Marina Ilicic
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Marina Ilicic
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Marina Ilicic
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Murielle G. Kluge
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Murielle G. Kluge
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Murielle G. Kluge
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Clifford TeBay
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Clifford TeBay
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Clifford TeBay
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Ole P. Ottersen
- Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
- Ole P. Ottersen
- Office of the President, Karolinska Institutet, Stockholm, Sweden
- Sarah J. Johnson
- School of Electrical Engineering and Computing, University of Newcastle, Newcastle, NSW, Australia
- Sarah J. Johnson
- Centre for Rehab Innovations, University of Newcastle, Newcastle, NSW, Australia
- Michael Nilsson
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Michael Nilsson
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Michael Nilsson
- National Health and Medical Research Council Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, Heidelberg, VIC, Australia
- Michael Nilsson
- Centre for Rehab Innovations, University of Newcastle, Newcastle, NSW, Australia
- Frederick R. Walker
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia
- Frederick R. Walker
- Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
- Frederick R. Walker
- Hunter Medical Research Institute, Newcastle, NSW, Australia
- Frederick R. Walker
- National Health and Medical Research Council Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, Heidelberg, VIC, Australia
- Frederick R. Walker
- Centre for Rehab Innovations, University of Newcastle, Newcastle, NSW, Australia
- DOI
- https://doi.org/10.3389/fneur.2021.585189
- Journal volume & issue
-
Vol. 12
Abstract
Cognitive impairment is a common and disruptive outcome for stroke survivors, which is recognized to be notoriously difficult to treat. Previously, we have shown that low oxygen post-conditioning (LOPC) improves motor function and limits secondary neuronal loss in the thalamus after experimental stroke. There is also emerging evidence that LOPC may improve cognitive function post-stroke. In the current study we aimed to explore how exposure to LOPC may improve cognition post-stroke. Experimental stroke was induced using photothrombotic occlusion in adult, male C57BL/6 mice. At 72 h post-stroke animals were randomly assigned to either normal atmospheric air or to one of two low oxygen (11% O2) exposure groups (either 8 or 24 h/day for 14 days). Cognition was assessed during the treatment phase using a touchscreen based paired-associate learning assessment. At the end of treatment (17 days post-stroke) mice were euthanized and tissue was collected for subsequent histology and biochemical analysis. LOPC (both 8 and 24 h) enhanced learning and memory in the 2nd week post-stroke when compared with stroke animals exposed to atmospheric air. Additionally we observed LOPC was associated with lower levels of neuronal loss, the restoration of several vascular deficits, as well as a reduction in the severity of the amyloid-beta (Aβ) burden. These findings provide further insight into the pro-cognitive benefits of LOPC.
Keywords
