Thiamine mediated reversal of left ventricular dysfunction in patients with alcoholic cardiomyopathy

Abstract

This study aimed to evaluate the effect of thiamine supplementation on left ventricular (LV) systolic function in patients of alcoholic cardiomyopathy(ACM) presenting with acute heart failure(HF). 11 newly diagnosed patients were included. They were treated with 3 days of intravenous(IV) therapy with thiamine followed by oral supplementation. LVEF was 30% at baseline which improved by 45% and 53% along with reduction in LV dimensions over 3 and 6 months respectively. The study suggests the benefit of thiamine supplementation on LVEF in ACM patients with HF.

Keywords

• Alcoholic cardiomyopathy(ACM)
• Heart failure(HF)
• Left ventricular end diastolic
• diameter(LVEDD)
• Left ventricular end systolic diameter(LVESD)
• Thiamine deficiency(TD)