Nature Communications (Mar 2017)

A redox-mediated Kemp eliminase

  • Aitao Li,
  • Binju Wang,
  • Adriana Ilie,
  • Kshatresh D. Dubey,
  • Gert Bange,
  • Ivan V. Korendovych,
  • Sason Shaik,
  • Manfred T. Reetz

DOI
https://doi.org/10.1038/ncomms14876
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 8

Abstract

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The majority of enzymatic Kemp elimination reactions proceed via a well-established acid-base mechanism. Here, the authors show that cytochrome P450 is able to metabolize the leflunomide drug via a redox Kemp elimination, offering new insights into enzyme catalysis.