Nature Communications (Jun 2018)

HuR regulates telomerase activity through TERC methylation

  • Hao Tang,
  • Hu Wang,
  • Xiaolei Cheng,
  • Xiuqin Fan,
  • Fan Yang,
  • Mengmeng Zhang,
  • Yanlian Chen,
  • Yuyang Tian,
  • Cihang Liu,
  • Dongxing Shao,
  • Bin Jiang,
  • Yali Dou,
  • Yusheng Cong,
  • Junyue Xing,
  • Xiaotian Zhang,
  • Xia Yi,
  • Zhou Songyang,
  • Wenbin Ma,
  • Yong Zhao,
  • Xian Wang,
  • Jinbiao Ma,
  • Myriam Gorospe,
  • Zhenyu Ju,
  • Wengong Wang

DOI
https://doi.org/10.1038/s41467-018-04617-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

Mutations in the RNA component TERC can cause telomerase dysfunction but the underlying mechanisms are largely unknown. Here, the authors show that RNA-binding protein HuR regulates telomerase function by enhancing the methylation of TERC, which is impaired by several disease-relevant TERC mutations.