Stem cell induced inflammatory hypertrophy of the cauda equina

Aaron D. Brumbaugh, MD; Alan Podolsky, MD; Matthew H. Kulzer, MD; Michael P. Spearman, MD; Michael F. Goldberg, MD, MPH; Warren M. Chang, MD, MBA; Nazia Khatoon, MD; Kossivi Dantey, MD; Charles Q. Li, MD

Radiology Case Reports (May 2022)

Stem cell induced inflammatory hypertrophy of the cauda equina

Aaron D. Brumbaugh, MD,
Alan Podolsky, MD,
Matthew H. Kulzer, MD,
Michael P. Spearman, MD,
Michael F. Goldberg, MD, MPH,
Warren M. Chang, MD, MBA,
Nazia Khatoon, MD,
Kossivi Dantey, MD,
Charles Q. Li, MD

Affiliations

Aaron D. Brumbaugh, MD: Imaging Institute, Allegheny Health Network, Pittsburgh, PA, USA
Alan Podolsky, MD: Imaging Institute, Allegheny Health Network, Pittsburgh, PA, USA
Matthew H. Kulzer, MD: Imaging Institute, Allegheny Health Network, Pittsburgh, PA, USA
Michael P. Spearman, MD: Imaging Institute, Allegheny Health Network, Pittsburgh, PA, USA
Michael F. Goldberg, MD, MPH: Imaging Institute, Allegheny Health Network, Pittsburgh, PA, USA
Warren M. Chang, MD, MBA: Imaging Institute, Allegheny Health Network, Pittsburgh, PA, USA
Nazia Khatoon, MD: Pathology Institute, Allegheny Health Network, Pittsburgh, PA, USA
Kossivi Dantey, MD: Pathology Institute, Allegheny Health Network, Pittsburgh, PA, USA
Charles Q. Li, MD: Imaging Institute, Allegheny Health Network, Pittsburgh, PA, USA; Corresponding author.

Journal volume & issue: Vol. 17, no. 5
pp. 1601 – 1604

Abstract

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Stem cell therapy can present clinicians with challenging clinical scenarios, as access to such treatments outpaces the research into their efficacy and safety due to the burgeoning trend of international travel to acquire stem cell therapy, or “stem cell tourism.” Treatment of neurologic conditions remains an enticing potential application of stem cell therapy, often administered intrathecally. In response to such therapy, multiple adverse events have been described in the literature, including neoplasms, demyelinating disease, and seizures, among others. We present a case of symptomatic inflammatory cauda equina nerve root hypertrophy due to intrathecal stem cell infusion, representing a rare but significant complication.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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