Nature Communications (Aug 2022)
Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform
- William Whyte,
- Debkalpa Goswami,
- Sophie X. Wang,
- Yiling Fan,
- Niamh A. Ward,
- Ruth E. Levey,
- Rachel Beatty,
- Scott T. Robinson,
- Declan Sheppard,
- Raymond O’Connor,
- David S. Monahan,
- Lesley Trask,
- Keegan L. Mendez,
- Claudia E. Varela,
- Markus A. Horvath,
- Robert Wylie,
- Joanne O’Dwyer,
- Daniel A. Domingo-Lopez,
- Arielle S. Rothman,
- Garry P. Duffy,
- Eimear B. Dolan,
- Ellen T. Roche
Affiliations
- William Whyte
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology
- Debkalpa Goswami
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology
- Sophie X. Wang
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology
- Yiling Fan
- Department of Mechanical Engineering, Massachusetts Institute of Technology
- Niamh A. Ward
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology
- Ruth E. Levey
- Anatomy and Regenerative Medicine Institute (REMEDI), National University of Ireland Galway
- Rachel Beatty
- Anatomy and Regenerative Medicine Institute (REMEDI), National University of Ireland Galway
- Scott T. Robinson
- Anatomy and Regenerative Medicine Institute (REMEDI), National University of Ireland Galway
- Declan Sheppard
- Department of Radiology, University Hospital
- Raymond O’Connor
- Anatomy and Regenerative Medicine Institute (REMEDI), National University of Ireland Galway
- David S. Monahan
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology
- Lesley Trask
- Department of Biomedical Engineering, National University of Ireland Galway
- Keegan L. Mendez
- Harvard-MIT Program in Health Sciences and Technology
- Claudia E. Varela
- Harvard-MIT Program in Health Sciences and Technology
- Markus A. Horvath
- Harvard-MIT Program in Health Sciences and Technology
- Robert Wylie
- Anatomy and Regenerative Medicine Institute (REMEDI), National University of Ireland Galway
- Joanne O’Dwyer
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology
- Daniel A. Domingo-Lopez
- Anatomy and Regenerative Medicine Institute (REMEDI), National University of Ireland Galway
- Arielle S. Rothman
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology
- Garry P. Duffy
- Anatomy and Regenerative Medicine Institute (REMEDI), National University of Ireland Galway
- Eimear B. Dolan
- Department of Biomedical Engineering, National University of Ireland Galway
- Ellen T. Roche
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology
- DOI
- https://doi.org/10.1038/s41467-022-32147-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Drug delivery implants suffer from diminished release profiles due to fibrous capsule formation over time. Here, the authors use soft robotic actuation to modulate the immune response of the host to maintain drug delivery over the longer-term and to perform controlled release in vivo.
