Nature Communications (Sep 2016)

Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome

  • Richard S. Beard,
  • Xiaoyuan Yang,
  • Jamie E. Meegan,
  • Jonathan W. Overstreet,
  • Clement G.Y. Yang,
  • John A. Elliott,
  • Jason J. Reynolds,
  • Byeong J. Cha,
  • Christopher D. Pivetti,
  • David A. Mitchell,
  • Mack H. Wu,
  • Robert J. Deschenes,
  • Sarah Y. Yuan

DOI
https://doi.org/10.1038/ncomms12823
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 19

Abstract

Read online

Breaking down the endothelial barrier is a hallmark of systemic inflammatory response syndrome. Here the authors show that palmitoylation, a post-translational modification of proteins, plays a critical role in altering endothelial function during inflammation, and suggest the targeting of palmitoyl acyltransferase DHHC21 as potential disease therapy.