Nature Communications (Aug 2017)

ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

  • Zaniar Ghazizadeh,
  • Der-I Kao,
  • Sadaf Amin,
  • Brandoch Cook,
  • Sahana Rao,
  • Ting Zhou,
  • Tuo Zhang,
  • Zhaoying Xiang,
  • Reyn Kenyon,
  • Omer Kaymakcalan,
  • Chengyang Liu,
  • Todd Evans,
  • Shuibing Chen

DOI
https://doi.org/10.1038/s41467-017-00129-y
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

Our incomplete understanding of how pancreatic beta cells form limits the generation of beta-like cells from human pluripotent stem cells (hPSC). Here, the authors identify a ROCKII inhibitor H1152 as increasing insulin secreting cells from hPSCs and improving beta-cell maturation on transplantation in vivo.