Molecular and clinical aspects of HNSCC in the Republic of Moldova

Abstract

Introduction: Complex molecular characterization and integrated approaches in the basic research of HNSCC provide new insights into the understanding and treatment of these tumors. Mutations in the TP53 gene, HPV infection, aberrant DNA methylation are just a few factors that have a direct link with the clinical and psychological condition of patients with this type of cancer. In the Republic of Moldova, these aspects are insufficiently studied.

Keywords

• psychological stress
• hnscc
• tp53
• high risk hpv
• global methylation