Nature Communications (Mar 2021)

Transcription organizes euchromatin via microphase separation

  • Lennart Hilbert,
  • Yuko Sato,
  • Ksenia Kuznetsova,
  • Tommaso Bianucci,
  • Hiroshi Kimura,
  • Frank Jülicher,
  • Alf Honigmann,
  • Vasily Zaburdaev,
  • Nadine L. Vastenhouw

DOI
https://doi.org/10.1038/s41467-021-21589-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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How euchromatin organisation and transcription are related is unclear. Here, the authors observe the dynamics of euchromatin organization showing that accumulating RNA recruits RNA-binding proteins that together with transcribed euchromatin separate from non-transcribed euchromatin, forming microphases.