Fibronectin binding protein B binds to loricrin and promotes corneocyte adhesion by Staphylococcus aureus

Thaina M. da Costa; Albertus Viljoen; Aisling M. Towell; Yves F. Dufrêne; Joan A. Geoghegan

doi:10.1038/s41467-022-30271-1

Nature Communications (May 2022)

Fibronectin binding protein B binds to loricrin and promotes corneocyte adhesion by Staphylococcus aureus

Thaina M. da Costa,
Albertus Viljoen,
Aisling M. Towell,
Yves F. Dufrêne,
Joan A. Geoghegan

Affiliations

Thaina M. da Costa: Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin
Albertus Viljoen: Louvain Institute of Biomolecular Science and Technology, UC Louvain
Aisling M. Towell: Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin
Yves F. Dufrêne: Louvain Institute of Biomolecular Science and Technology, UC Louvain
Joan A. Geoghegan: Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin

DOI: https://doi.org/10.1038/s41467-022-30271-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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The first step during skin colonization by is its adhesion to corneocytes. Da Costa et al. show that the cell wall-anchored fibronectin binding protein B (FnBPB) of S. aureus binds to loricrin. Applying single cell force spectroscopy, they demonstrate that this interaction promotes adhesion of S. aureus to human corneocytes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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