Molecules (Nov 2021)

Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles

  • Xiang-Kui He,
  • Juan Lu,
  • Hai-Bing Ye,
  • Lei Li,
  • Jun Xuan

DOI
https://doi.org/10.3390/molecules26226843
Journal volume & issue
Vol. 26, no. 22
p. 6843

Abstract

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An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitriles to synthesise biologically important phenanthridines. The synthetic value of this protocol can be further illustrated by the modification of quinoxalin-2-ones, containing important natural products and drug-based complex molecules.

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