Nature Communications (Nov 2019)

An open source automated tumor infiltrating lymphocyte algorithm for prognosis in melanoma

  • Balazs Acs,
  • Fahad Shabbir Ahmed,
  • Swati Gupta,
  • Pok Fai Wong,
  • Robyn D. Gartrell,
  • Jaya Sarin Pradhan,
  • Emanuelle M. Rizk,
  • Bonnie Gould Rothberg,
  • Yvonne M. Saenger,
  • David L. Rimm

DOI
https://doi.org/10.1038/s41467-019-13043-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 7

Abstract

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Histology data exists for many cancer samples and the ability to automatically image this data may provide prognostic information. Here, the authors generated an algorithm to measure tumour infiltrating lymphocytes in melanoma histology specimens and show that the ratio of these immune cells to tumour cells has prognostic value.