Journal of Clinical Medicine (Mar 2023)
Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
- Giuseppe De Luca,
- Magdy Algowhary,
- Berat Uguz,
- Dinaldo C. Oliveira,
- Vladimir Ganyukov,
- Oliver Busljetik,
- Miha Cercek,
- Lisette Okkels Jensen,
- Poay Huan Loh,
- Lucian Calmac,
- Gerard Roura i Ferrer,
- Alexandre Quadros,
- Marek Milewski,
- Fortunato Scotto D’Uccio,
- Clemens von Birgelen,
- Francesco Versaci,
- Jurrien Ten Berg,
- Gianni Casella,
- Aaron Wong Sung Lung,
- Petr Kala,
- José Luis Díez Gil,
- Xavier Carrillo,
- Maurits Dirksen,
- Victor Becerra Munoz,
- Michael Kang-yin Lee,
- Dafsah Arifa Juzar,
- Rodrigo de Moura Joaquim,
- Roberto Paladino,
- Davor Milicic,
- Periklis Davlouros,
- Nikola Bakraceski,
- Filippo Zilio,
- Luca Donazzan,
- Adriaan Kraaijeveld,
- Gennaro Galasso,
- Lux Arpad,
- Lucia Marinucci,
- Vincenzo Guiducci,
- Maurizio Menichelli,
- Alessandra Scoccia,
- Aylin Hatice Yamac,
- Kadir Ugur Mert,
- Xacobe Flores Rios,
- Tomas Kovarnik,
- Michal Kidawa,
- Josè Moreu,
- Vincent Flavien,
- Enrico Fabris,
- Iñigo Lozano Martínez-Luengas,
- Marco Boccalatte,
- Francisco Bosa Ojeda,
- Carlos Arellano-Serrano,
- Gianluca Caiazzo,
- Giuseppe Cirrincione,
- Hsien-Li Kao,
- Juan Sanchis Forés,
- Luigi Vignali,
- Helder Pereira,
- Stephane Manzo-Silberman,
- Santiago Ordoñez,
- Alev Arat Özkan,
- Bruno Scheller,
- Heidi Lehitola,
- Rui Teles,
- Christos Mantis,
- Ylitalo Antti,
- João António Brum Silveira,
- Cesar Rodrigo Zoni,
- Ivan Bessonov,
- Giuseppe Uccello,
- George Kochiadakis,
- Dimitrios Alexopulos,
- Carlos E. Uribe,
- John Kanakakis,
- Benjamin Faurie,
- Gabriele Gabrielli,
- Alejandro Gutierrez Barrios,
- Juan Pablo Bachini,
- Alex Rocha,
- Frankie C. C. Tam,
- Alfredo Rodriguez,
- Antonia Anna Lukito,
- Veauthyelau Saint-Joy,
- Gustavo Pessah,
- Andrea Tuccillo,
- Alfonso Ielasi,
- Giuliana Cortese,
- Guido Parodi,
- Mohammed Abed Burgadha,
- Elvin Kedhi,
- Pablo Lamelas,
- Harry Suryapranata,
- Matteo Nardin,
- Monica Verdoia
Affiliations
- Giuseppe De Luca
- Division of Cardiology, AOU Policlinico G Martino, 98124 Messina, Italy
- Magdy Algowhary
- Division of Cardiology, Assiut University Heart Hospital, Assiut University, Asyut 71515, Egypt
- Berat Uguz
- Division of Cardiology, Bursa City Hospital, 16110 Bursa, Türkiye
- Dinaldo C. Oliveira
- Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal University of Pernambuco, Recife 1235, Brazil
- Vladimir Ganyukov
- Department of Heart and Vascular Surgery, State Research Institute for Complex Issues of Cardiovascular Diseases, 653002 Kemerovo, Russia
- Oliver Busljetik
- University Clinic for Cardiology, Medical Faculty, Ss’ Cyril and Methodius University, 1000 Skopje, North Macedonia
- Miha Cercek
- Department of Cardiology, Medical Center Ljubljana, 1000 Ljubljana, Slovenia
- Lisette Okkels Jensen
- Division of Cardiology, Odense Universitets Hospital, 5000 Odense, Denmark
- Poay Huan Loh
- Department of Cardiology, National University Hospital, Singapore 119074, Singapore
- Lucian Calmac
- Clinic Emergency Hospital of Bucharest, 010001 Bucharest, Romania
- Gerard Roura i Ferrer
- Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, 08016 Barcelona, Spain
- Alexandre Quadros
- Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre 90000-00, Brazil
- Marek Milewski
- Division of Cardiology, Medical University of Silezia, 40-002 Katowice, Poland
- Fortunato Scotto D’Uccio
- Division of Cardiology, Ospedale del Mare, 80147 Napoli, Italy
- Clemens von Birgelen
- Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, 7541 Enschede, The Netherlands
- Francesco Versaci
- Division of Cardiology, Ospedale Santa Maria Goretti Latina, 04100 Latina, Italy
- Jurrien Ten Berg
- Division of Cardiology, St Antonius Hospital, 3434 Nieuwegein, The Netherlands
- Gianni Casella
- Division of Cardiology, Ospedale Maggiore Bologna, 40100 Bologna, Italy
- Aaron Wong Sung Lung
- Department of Cardiology, National Heart Center, Singapore 169609, Singapore
- Petr Kala
- University Hospital Brno, Medical Faculty of Masaryk University Brno, 60200 Bohunice, Czech Republic
- José Luis Díez Gil
- Cardiology, H. Universitario y Politécnico La Fe, 46001 Valencia, Spain
- Xavier Carrillo
- Hospital Germans Triasi Pujol, 8918 Badalona, Spain
- Maurits Dirksen
- Division of Cardiology, Northwest Clinics, 1811 Alkmaar, The Netherlands
- Victor Becerra Munoz
- Hospital Clínico Universitario Virgen de la Victoria, 290000 Malaga, Spain
- Michael Kang-yin Lee
- Department of Cardiology, Queen Elizabeth Hospital, University of Hong Kong, Hong Kong
- Dafsah Arifa Juzar
- Department of Cardiology and Vascular Medicine, University of Indonesia National Cardiovascular Center “Harapan Kita”, Jakarta 11402, Indonesia
- Rodrigo de Moura Joaquim
- Instituto de Cardiologia de Santa Catarina Praia Comprida, São José 88100-000, Brazil
- Roberto Paladino
- Division of Cardiology, Clinica Villa dei Fiori, 80011 Acerra, Italy
- Davor Milicic
- Department of Cardiology, University Hospital Centre, University of Zagreb, 10000 Zagreb, Croatia
- Periklis Davlouros
- Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, 26221 Patras, Greece
- Nikola Bakraceski
- Center for Cardiovascular Diseases, 6000 Ohrid, North Macedonia
- Filippo Zilio
- Division of Cardiology, Ospedale Santa Chiara di Trento, 38014 Trento, Italy
- Luca Donazzan
- Division of Cardiology, Ospedale ”S. Maurizio”, 39100 Bolzano, Italy
- Adriaan Kraaijeveld
- Division of Cardiology, UMC Utrecht, 3584 Utrecht, The Netherlands
- Gennaro Galasso
- Division of Cardiology, Ospedale San Giovanni di Dio e Ruggid’Aragona, 84070 Salerno, Italy
- Lux Arpad
- Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands
- Lucia Marinucci
- Division of Cardiology, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, 61121 Pesaro, Italy
- Vincenzo Guiducci
- Division of Cardiology, AUSL-IRCCS Reggio Emilia, 42121 Reggio Emilia, Italy
- Maurizio Menichelli
- Division of Cardiology, Ospedale “F. Spaziani“, 03100 Frosinone, Italy
- Alessandra Scoccia
- Division of Cardiology, Ospedale “Sant’Anna”, 44121 Ferrara, Italy
- Aylin Hatice Yamac
- Department of Cardiology, Hospital Bezmialem Vakıf University, 34093 Istanbul, Türkiye
- Kadir Ugur Mert
- Division of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, 02640 Eskisehir, Türkiye
- Xacobe Flores Rios
- Complexo Hospetaliero Universitario La Coruna, 15001 La Coruna, Spain
- Tomas Kovarnik
- University Hospital Prague, 12808 Prague, Czech Republic
- Michal Kidawa
- Central Hospital, Medical University of Lodz, 90-008 Lodz, Poland
- Josè Moreu
- Division of Cardiology, Complejo Hospitalario de Toledo, 45001 Toledo, Spain
- Vincent Flavien
- Division of Cardiology, Center Hospitalier Universitaire de Lille, 59000 Lille, France
- Enrico Fabris
- Azienda Ospedaliero, Universitaria Ospedali Riuniti Trieste, 34142 Trieste, Italy
- Iñigo Lozano Martínez-Luengas
- Division of Cardiology, Hospital Cabueñes, 33201 Gijon, Spain
- Marco Boccalatte
- Division of Cardiology, Ospedale Santa Maria delle Grazie, 80078 Pozzuoli, Italy
- Francisco Bosa Ojeda
- Division of Cardiology, Hospital Universitario de Canarias, 38001 Santa Cruz de Tenerife, Spain
- Carlos Arellano-Serrano
- Division of Cardiology, Hospital Puerta de Hierro Majadahonda, 28222 Madrid, Spain
- Gianluca Caiazzo
- Division of Cardiology, Ospedale “G Moscati”, 81031 Aversa, Italy
- Giuseppe Cirrincione
- Division of Cardiology, Ospedale Civico Arnas, 90100 Palermo, Italy
- Hsien-Li Kao
- Cardiology Division, Department of Internal Medicine, National Taiwan University Hospital, 8865, Taipei 600, Taiwan
- Juan Sanchis Forés
- Division of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain
- Luigi Vignali
- Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, 43121 Parma, Italy
- Helder Pereira
- Cardiology Department, Hospital Garcia de Orta, Pragal, 2805-267 Almada, Portugal
- Stephane Manzo-Silberman
- Division of Cardiology, CHU Lariboisière, AP-HP, Paris VII University, INSERM UMRS 942, 75010 Paris, France
- Santiago Ordoñez
- Instituto Cardiovascular de Buenos Aires, 6302, Buenos Aires C1428 CABA, Argentina
- Alev Arat Özkan
- Cardiology Institute, Instanbul University, 34000 Istanbul, Türkiye
- Bruno Scheller
- Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, 66421 Saarland, Germany
- Heidi Lehitola
- Division of Cardiology, Oulu University Hospital, 90220 Oulu, Finland
- Rui Teles
- Division of Cardiology, Hospital de Santa Cruz, CHLO-Nova Medical School, 1000 Lisbon, Portugal
- Christos Mantis
- Division of Cardiology, Kontantopoulion Hospital, 10431 Athens, Greece
- Ylitalo Antti
- Division of Cardiology, Heart Centre Turku, 20521 Turku, Finland
- João António Brum Silveira
- Division of Cardiology, Hospital de Santo António, 4099-001 Porto, Portugal
- Cesar Rodrigo Zoni
- Department of Teaching and Research, Instituto de Cardiología de Corrientes “Juana F. Cabral”, Corrientes W3400CDS, Argentina
- Ivan Bessonov
- Tyumen Cardiology Research Center, 625026 Tyumen, Russia
- Giuseppe Uccello
- Division of Cardiology, Ospedale “A. Manzoni”, 23900 Lecco, Italy
- George Kochiadakis
- Iraklion University Hospital, 70001 Crete, Greece
- Dimitrios Alexopulos
- Division of Cardiology, Attikon University Hospital, 10431 Athens, Greece
- Carlos E. Uribe
- Division of Cardiology, Universidad UPB-CES, Medellin 050001, Colombia
- John Kanakakis
- Division of Cardiology, Alexandra Hospital, 10431 Athens, Greece
- Benjamin Faurie
- Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, 38000 Grenoble, France
- Gabriele Gabrielli
- Interventional Cardiolgy Unit, IRCCS INRCA, 60131 Ancona, Italy
- Alejandro Gutierrez Barrios
- Division of Cardiology, Hospital Puerta del Mar, 11001 Cadiz, Spain
- Juan Pablo Bachini
- Instituto de Cardiologia Integral, Montevideo 11700, Uruguay
- Alex Rocha
- Department of Cardiology and Cardiovascular Interventions, Instituto Nacional de Cirugía Cardíaca, Montevideo 11700, Uruguay
- Frankie C. C. Tam
- Department of Cardiology, Queen Mary Hospital, University of Hong Kong, Hong Kong
- Alfredo Rodriguez
- Division of Cardiology, Otamendi Hospital, Buenos Aires 1001, Argentina
- Antonia Anna Lukito
- Heart Center Siloam Lippo Village Hospital, Cardiovascular Department Pelita Harapan University, Tangerang 15810, Indonesia
- Veauthyelau Saint-Joy
- Center Hospitalierd’Antibes Juan Les Pins, 06600 Antibes, France
- Gustavo Pessah
- Division of Cardiology, Hospital Cordoba, Cordoba 5000, Argentina
- Andrea Tuccillo
- Division of Cardiology, Ospedale del Mare, 80147 Napoli, Italy
- Alfonso Ielasi
- Division of Cardiology, Galeazzi-Sant’Ambrogio Hospital, 20157 Milan, Italy
- Giuliana Cortese
- Department of Statistical Sciences, University of Padova, 35121 Padova, Italy
- Guido Parodi
- Cardiology, Azienda Ospedaliera Lavagna, 16033 Lavagna, Italy
- Mohammed Abed Burgadha
- Division of Cardiology, Blida University Hospital, Blida 0900, Algeria
- Elvin Kedhi
- Division of Cardiology, Hopital Erasmus, Universitè Libre de Bruxelles, 1050 Bruxelles, Belgium
- Pablo Lamelas
- Instituto Cardiovascular de Buenos Aires, 6302, Buenos Aires C1428 CABA, Argentina
- Harry Suryapranata
- Division of Cardiology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands
- Matteo Nardin
- Department of Internal Medicine, Ospedale Riuniti, 25121 Brescia, Italy
- Monica Verdoia
- Division of Cardiology, Ospedale degli Infermi, ASL, 13900 Biella, Italy
- DOI
- https://doi.org/10.3390/jcm12062116
- Journal volume & issue
-
Vol. 12,
no. 6
p. 2116
Abstract
Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (p p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.
Keywords