Trial Direct Phasing Calculation of A Thyroid Hormone Receptor Alpha Structure (4LNW)

Abstract

A thyroid receptor alpha structure (PDB ID: 4LNW) was studied for ab initio phasing. With the diffraction intensity data, protein sequence, and ligand structure as the only input, a high-resolution structure was successfully reconstructed by using an iterative projective method based on the hybrid input−output (HIO) algorithm.

Keywords

• ab initio phasing
• iterative projection algorithm
• protein crystallography