GENETICS OF SUSCEPTIBILITY TO HUMAN HELMINTHIASIS

Abstract

Objective of research: to provide the analysis of literature sources describing the in uence of host genes on genetic susceptibility to helminthiasis and the features of its pathogenesis. Results and discussion: all recent scienti c works dedicated to the in uence of host genes on genetic susceptibility to helminthiasis and the features of its pathogenesis were considered. The most important determinants of impact of host genes on genetic susceptibility to helminthiasis are gene polymorphisms TAP for echinococcosis, variants of genetic loci SM1 and SM2 for bilharziasis (schistosomiasis), and gene polymorphisms HLA for all three parasitic diseases described in this article.

Keywords

• genetics
• susceptibility
• helminthiasis
• schistosomiasis
• echinococcosis
• anisakiasis
• polymorphism
• immune response