Dysregulated transforming growth factor-beta mediates early bone marrow dysfunction in diabetes

Jina J. Y. Kum; Christopher J. Howlett; Zia A. Khan

doi:10.1038/s42003-022-04112-2

Communications Biology (Oct 2022)

Dysregulated transforming growth factor-beta mediates early bone marrow dysfunction in diabetes

Jina J. Y. Kum,
Christopher J. Howlett,
Zia A. Khan

Affiliations

Jina J. Y. Kum: Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University
Christopher J. Howlett: Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University
Zia A. Khan: Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University

DOI: https://doi.org/10.1038/s42003-022-04112-2
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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Short-term diabetes in mice suppresses transforming growth factor-beta (TGFB) signalling to enhance adipogenesis in the tibiae marrow mesenchymal progenitor cells. Inhibition of adipogenic differentiation by TGFB is mediated through TAK1.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal