Heart-Ankle Pulse Wave Velocity Is Superior to Brachial-Ankle Pulse Wave Velocity in Detecting Aldosterone-Induced Arterial Stiffness

Zheng-Wei Chen; Chien-Ting Pan; Cheng-Hsuan Tsai; Yi-Yao Chang; Chin-Chen Chang; Bo-Ching Lee; Yu-Wei Chiu; Wei-Chieh Huang; Yu-Li Lin; Vin-Cent Wu; Chi-Sheng Hung; Che-Wei Liao; Yen-Hung Lin; on behalf of TAIPAI Study Group

doi:10.3390/biomedicines9101285

Biomedicines (Sep 2021)

Heart-Ankle Pulse Wave Velocity Is Superior to Brachial-Ankle Pulse Wave Velocity in Detecting Aldosterone-Induced Arterial Stiffness

Zheng-Wei Chen,
Chien-Ting Pan,
Cheng-Hsuan Tsai,
Yi-Yao Chang,
Chin-Chen Chang,
Bo-Ching Lee,
Yu-Wei Chiu,
Wei-Chieh Huang,
Yu-Li Lin,
Vin-Cent Wu,
Chi-Sheng Hung,
Che-Wei Liao,
Yen-Hung Lin,
on behalf of TAIPAI Study Group

Affiliations

Zheng-Wei Chen: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
Chien-Ting Pan: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
Cheng-Hsuan Tsai: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
Yi-Yao Chang: Department of Cardiovascular Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan
Chin-Chen Chang: Department of Medical Imaging, College of Medicine, National Taiwan University Hospital and National Taiwan University, Taipei 100, Taiwan
Bo-Ching Lee: Department of Medical Imaging, College of Medicine, National Taiwan University Hospital and National Taiwan University, Taipei 100, Taiwan
Yu-Wei Chiu: Department of Cardiovascular Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan
Wei-Chieh Huang: Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
Yu-Li Lin: Department of Business Administration and Graduate School of Service Management, Chihlee University of Technology, New Taipei City 220, Taiwan
Vin-Cent Wu: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
Chi-Sheng Hung: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
Che-Wei Liao: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
Yen-Hung Lin: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
on behalf of TAIPAI Study Group

DOI: https://doi.org/10.3390/biomedicines9101285
Journal volume & issue: Vol. 9, no. 10
p. 1285

Abstract

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Primary aldosteronism (PA) is associated with higher arterial stiffness compared to essential hypertension (EH). However, few studies have compared different pulse wave velocity (PWV) parameters to detect aldosterone-induced arterial stiffness. In this study, we aimed to compare the sensitivity in detecting aldosterone-induced arterial stiffness between brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV). We prospectively enrolled 1006 PA patients and 983 EH patients. Detailed medical history, basic biochemistry data and two PWV measurements (baPWV and haPWV) were collected in both groups. We performed analysis on the original cohort and two propensity score matching (PSM) models (model 1 adjusted for age and sex; model 2 adjusted for age, sex, systolic and diastolic blood pressure). The DeLong test was used to compare areas under receiver operating characteristic curves (AUCs) between baPWV and haPWV to predict PA. In all models, the PA patients had significantly higher baPWV compared to the EH patients. The AUC of haPWV was greater than that of baPWV. In conclusion, haPWV seems to be a better PWV parameter than baPWV in detecting aldosterone-induced arterial stiffness.

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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