Nature Communications (Mar 2022)
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy
- Jianjie Li,
- Xiaodong Shu,
- Jun Xu,
- Sek Man Su,
- Un In Chan,
- Lihua Mo,
- Jianlin Liu,
- Xin Zhang,
- Ragini Adhav,
- Qiang Chen,
- Yuqing Wang,
- Tingting An,
- Xu Zhang,
- Xueying Lyu,
- Xiaoling Li,
- Josh Haipeng Lei,
- Kai Miao,
- Heng Sun,
- Fuqiang Xing,
- Aiping Zhang,
- Chuxia Deng,
- Xiaoling Xu
Affiliations
- Jianjie Li
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xiaodong Shu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Jun Xu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Sek Man Su
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Un In Chan
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Lihua Mo
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Jianlin Liu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xin Zhang
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Ragini Adhav
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Qiang Chen
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Yuqing Wang
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Tingting An
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xu Zhang
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xueying Lyu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xiaoling Li
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Josh Haipeng Lei
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Kai Miao
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Heng Sun
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Fuqiang Xing
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Aiping Zhang
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Chuxia Deng
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xiaoling Xu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- DOI
- https://doi.org/10.1038/s41467-022-29151-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Defects in BRCA1, a gene involved in homologous recombination DNA repair, are common in triple negative breast cancer. Here the authors show that Brca1 deficiency in preclinical breast cancer models is associated with the accumulation of myeloid derived suppressive cells and resistance to immune checkpoint blockade, that could be overcome by targeting S100A9 and CXCL12.
