KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary

R. Tyler Hillman; Joseph Celestino; Christopher Terranova; Hannah C. Beird; Curtis Gumbs; Latasha Little; Tri Nguyen; Rebecca Thornton; Samantha Tippen; Jianhua Zhang; Karen H. Lu; David M. Gershenson; Kunal Rai; Russell R. Broaddus; P. Andrew Futreal

doi:10.1038/s41467-018-04950-x

Nature Communications (Jun 2018)

KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary

R. Tyler Hillman,
Joseph Celestino,
Christopher Terranova,
Hannah C. Beird,
Curtis Gumbs,
Latasha Little,
Tri Nguyen,
Rebecca Thornton,
Samantha Tippen,
Jianhua Zhang,
Karen H. Lu,
David M. Gershenson,
Kunal Rai,
Russell R. Broaddus,
P. Andrew Futreal

Affiliations

R. Tyler Hillman: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Joseph Celestino: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Christopher Terranova: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
Hannah C. Beird: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
Curtis Gumbs: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
Latasha Little: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
Tri Nguyen: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Rebecca Thornton: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
Samantha Tippen: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
Jianhua Zhang: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
Karen H. Lu: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
David M. Gershenson: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Kunal Rai: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
Russell R. Broaddus: Department of Pathology, The University of Texas MD Anderson Cancer Center
P. Andrew Futreal: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-018-04950-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 7

Abstract

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Adult-type granulosa cell tumors of the ovary (aGCTs) are rare and recurrence is difficult to treat. Here, the authors observe in aGCT a novel recurrent somatic truncating mutation of KMT2D, more frequent in recurrent aGCT, and also non-genetic loss of KMT2D expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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