PLoS ONE (Jan 2021)

Influence of polyvascular disease on clinical outcome in patients undergoing transcatheter aortic valve implantation via transfemoral access.

  • Masahiro Yamawaki,
  • Yosuke Honda,
  • Kenji Makino,
  • Takahide Nakano,
  • Yasunori Iida,
  • Fumiaki Yashima,
  • Hiroshi Ueno,
  • Kazuki Mizutani,
  • Minoru Tabata,
  • Norio Tada,
  • Kensuke Takagi,
  • Futoshi Yamanaka,
  • Toru Naganuma,
  • Yusuke Watanabe,
  • Masanori Yamamoto,
  • Shinichi Shirai,
  • Kentaro Hayashida,
  • OCEAN-TAVI registry

DOI
https://doi.org/10.1371/journal.pone.0260385
Journal volume & issue
Vol. 16, no. 12
p. e0260385

Abstract

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BackgroundThe influence of polyvascular disease (PVD) on the short- and long-term clinical outcomes of patients undergoing transcatheter aortic valve implantation via trans-femoral access (TF-TAVI) has not been fully elucidated.MethodsA total of 2167 patients from the Optimized CathEter vAlvular iNtervention-TAVI (OCEAN-TAVI) registry who underwent TF-TAVI was studied. PVD was defined as the presence of at least two of the following vascular bed (VB) diseases: concomitant coronary artery disease (CAD), cerebrovascular disease (CVD), and peripheral artery disease (PAD).ResultsPatients with PVD (288 patients, 13.3%) had a higher incidence of in-hospital complications, such as AKI (16.3% vs. 7.0%, pConclusionsThe increased prevalence of concomitant atherosclerotic VB diseases before TF-TAVI may increase the rates of in-hospital complications and 2-year cardiovascular death. Given the higher rate of mortality in patients with PVD undergoing TF-TAVI, future studies focusing on medical therapy are needed to reduce long-term cardiovascular events in this high-risk subset.