Myocardial and Pericardial Toxicity Associated With Immune Checkpoint Inhibitors in Cancer Patients

Johnny Chahine, MD; Patrick Collier, MD, PhD; Anjli Maroo, MD; W.H. Wilson Tang, MD; Allan L. Klein, MD

JACC: Case Reports (Feb 2020)

Myocardial and Pericardial Toxicity Associated With Immune Checkpoint Inhibitors in Cancer Patients

Johnny Chahine, MD,
Patrick Collier, MD, PhD,
Anjli Maroo, MD,
W.H. Wilson Tang, MD,
Allan L. Klein, MD

Affiliations

Johnny Chahine, MD: Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio
Patrick Collier, MD, PhD: Center for the Diagnosis and Treatment of Pericardial Diseases, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
Anjli Maroo, MD: Department of Cardiovascular Medicine, Cleveland Clinic Foundation Fairview Hospital, Cleveland, Ohio
W.H. Wilson Tang, MD: Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
Allan L. Klein, MD: Center for the Diagnosis and Treatment of Pericardial Diseases, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio; Address for correspondence: Dr. Allan L. Klein, Mail Code J1-5, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195.

Journal volume & issue: Vol. 2, no. 2
pp. 191 – 199

Abstract

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We recount a single-center experience with cardiac immunity-related adverse effects in patients treated with immune checkpoint inhibitors. Of 2,830 patients, 9 patients (0.3%) developed cardiac immunity-related adverse effects (4 cases of cardiomyopathies, 2 of myocarditis, 2 of acute pericarditis, and 1 of large pericardial effusion). Disease profiles, hospital courses, and outcomes are reported. (Level of Difficulty: Advanced.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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Abstract

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