Ecdysonelactones, Ecdysteroids from the Tropical Eastern Pacific Zoantharian Antipathozoanthus hickmani
Paul O. Guillen,
Kevin Calabro,
Karla B. Jaramillo,
Cristobal Dominguez,
Grégory Genta-Jouve,
Jenny Rodriguez,
Olivier P. Thomas
Affiliations
Paul O. Guillen
Escuela Superior Politécnica del Litoral, ESPOL, Centro Nacional de Acuacultura e Investigaciones Marinas, CENAIM, Campus Gustavo Galindo km. 30.5 vía Perimetral, Guayaquil P.O. Box 09-01-5863, Ecuador
Kevin Calabro
Marine Biodiscovery Laboratory, School of Chemistry and Ryan Institute, National University of Ireland, Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland
Karla B. Jaramillo
Escuela Superior Politécnica del Litoral, ESPOL, Centro Nacional de Acuacultura e Investigaciones Marinas, CENAIM, Campus Gustavo Galindo km. 30.5 vía Perimetral, Guayaquil P.O. Box 09-01-5863, Ecuador
Cristobal Dominguez
Escuela Superior Politécnica del Litoral, ESPOL, Centro Nacional de Acuacultura e Investigaciones Marinas, CENAIM, Campus Gustavo Galindo km. 30.5 vía Perimetral, Guayaquil P.O. Box 09-01-5863, Ecuador
Grégory Genta-Jouve
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8638 COMETE, Université Paris Descartes, 4 Avenue De L’observatoire, 75006 Paris, France
Jenny Rodriguez
Escuela Superior Politécnica del Litoral, ESPOL, Centro Nacional de Acuacultura e Investigaciones Marinas, CENAIM, Campus Gustavo Galindo km. 30.5 vía Perimetral, Guayaquil P.O. Box 09-01-5863, Ecuador
Olivier P. Thomas
Marine Biodiscovery Laboratory, School of Chemistry and Ryan Institute, National University of Ireland, Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland
Despite a large occurrence, especially over the Pacific Ocean, the chemical diversity of marine invertebrates belonging to the order Zoantharia is largely underexplored. For the two species of the genus Antipathozoanthus no chemical study has been reported so far. The first chemical investigation of Antipathozoanthus hickmani collected at the Marine Protected Area “El Pelado”, Santa Elena, Ecuador, led to the isolation of four new ecdysteroid derivatives named ecdysonelactones. The structures of ecdysonelactones A–D (1–4) were determined based on their spectroscopy data, including 1D and 2D NMR and HRMS. The four compounds of this family of ecdysteroids feature an unprecedented γ-lactone fused at the C-2/C-3 position of ring A. These derivatives exhibited neither antimicrobial nor cytotoxic activities.
