Nature Communications (Feb 2021)

Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation

  • Brittany C. Clawson,
  • Emily J. Pickup,
  • Amy Ensing,
  • Laura Geneseo,
  • James Shaver,
  • John Gonzalez-Amoretti,
  • Meiling Zhao,
  • A. Kane York,
  • Femke Roig Kuhn,
  • Kevin Swift,
  • Jessy D. Martinez,
  • Lijing Wang,
  • Sha Jiang,
  • Sara J. Aton

DOI
https://doi.org/10.1038/s41467-021-21471-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Learning-activated engram neurons play a critical role in memory recall but the role of these neurons in offline memory consolidation is unclear. The authors show that sleep-associated reactivation of learning-activated sensory neurons is necessary for memory consolidation.