Phytochemicals: Potential Therapeutic Modulators of Radiation Induced Signaling Pathways
Bimal Prasad Jit,
Biswajita Pradhan,
Rutumbara Dash,
Prajna Paramita Bhuyan,
Chhandashree Behera,
Rajendra Kumar Behera,
Ashok Sharma,
Miguel Alcaraz,
Mrutyunjay Jena
Affiliations
Bimal Prasad Jit
School of Life Sciences, Sambalpur University, Jyoti Vihar, Burla 768019, India
Biswajita Pradhan
Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India
Rutumbara Dash
School of Life Sciences, Sambalpur University, Jyoti Vihar, Burla 768019, India
Prajna Paramita Bhuyan
Department of Botany, Maharaja Sriram Chandra Bhanja Deo University, Baripada 757003, India
Chhandashree Behera
Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India
Rajendra Kumar Behera
School of Life Sciences, Sambalpur University, Jyoti Vihar, Burla 768019, India
Ashok Sharma
Department of Biochemistry, AIIMS, Ansari Nagar, New Delhi 110029, India
Miguel Alcaraz
Radiology and Physical Medicine Department, School of Medicine, Campus de Excelencia Internacional de Ámbito Regional (CEIR)-Campus Mare Nostrum (CMN), Universidad de Murcia, 30100 Murcia, Spain
Mrutyunjay Jena
Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India
Ionizing radiation results in extensive damage to biological systems. The massive amount of ionizing radiation from nuclear accidents, radiation therapy (RT), space exploration, and the nuclear battlefield leads to damage to biological systems. Radiation injuries, such as inflammation, fibrosis, and atrophy, are characterized by genomic instability, apoptosis, necrosis, and oncogenic transformation, mediated by the activation or inhibition of specific signaling pathways. Exposure of tumors or normal cells to different doses of ionizing radiation could lead to the generation of free radical species, which can release signal mediators and lead to harmful effects. Although previous FDA-approved agents effectively mitigate radiation-associated toxicities, their use is limited due to their high cellular toxicities. Preclinical and clinical findings reveal that phytochemicals derived from plants that exhibit potent antioxidant activities efficiently target several signaling pathways. This review examined the prospective roles played by some phytochemicals in altering signal pathways associated with radiation response.
