Clinical and Translational Medicine (Dec 2024)
Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information
- Lingrong Kong,
- Yingjun Yang,
- Chao Yuan,
- Xing Wei,
- Xinyao Zhou,
- Jia Zhou,
- Ya Xing,
- Gang Zou,
- Qianqian Sun,
- Luyao Cai,
- Qiufeng Liang,
- Yao Zhang,
- Hongkun Wang,
- Zesi Liu,
- Di Wu,
- Luming Sun
Affiliations
- Lingrong Kong
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Yingjun Yang
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Chao Yuan
- Research and Development DepartmentCelula (China) Medical Technology Co., Ltd.Chengdu China
- Xing Wei
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Xinyao Zhou
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Jia Zhou
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Ya Xing
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Gang Zou
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Qianqian Sun
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Luyao Cai
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Qiufeng Liang
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Yao Zhang
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Hongkun Wang
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Zesi Liu
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- Di Wu
- Research and Development DepartmentCelula (China) Medical Technology Co., Ltd.Chengdu China
- Luming Sun
- Department of Fetal Medicine & Prenatal Diagnosis CenterShanghai Key Laboratory of Maternal Fetal MedicineShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina
- DOI
- https://doi.org/10.1002/ctm2.70130
- Journal volume & issue
-
Vol. 14,
no. 12
pp. n/a – n/a
Abstract
Dear Editor, in this study, we propose a novel linkage disequilibrium information‐based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus‐specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost‐effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.
