Microbiota-derived acetate enhances host antiviral response via NLRP3

Junling Niu; Mengmeng Cui; Xin Yang; Juan Li; Yuhui Yao; Qiuhong Guo; Ailing Lu; Xiaopeng Qi; Dongming Zhou; Chenhong Zhang; Liping Zhao; Guangxun Meng

doi:10.1038/s41467-023-36323-4

Nature Communications (Feb 2023)

Microbiota-derived acetate enhances host antiviral response via NLRP3

Junling Niu,
Mengmeng Cui,
Xin Yang,
Juan Li,
Yuhui Yao,
Qiuhong Guo,
Ailing Lu,
Xiaopeng Qi,
Dongming Zhou,
Chenhong Zhang,
Liping Zhao,
Guangxun Meng

Affiliations

Junling Niu: The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences
Mengmeng Cui: The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences
Xin Yang: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Juan Li: The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences
Yuhui Yao: The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences
Qiuhong Guo: The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences
Ailing Lu: The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences
Xiaopeng Qi: CAS Key Laboratory of Animal Models and Human Disease Mechanisms/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
Dongming Zhou: The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences
Chenhong Zhang: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Liping Zhao: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Guangxun Meng: The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-023-36323-4
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

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The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production following influenza infection in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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