Molecular markers of VEGF, TNF-α and TNF-β IN bladder cancer patients at stage T3N0M0 and their relationship with the degree of tumor neoplasia

Abstract

17 bladder cancer patients, stage T3N0M0 (main group), were included in the study. There were 10 men (mean age 58.2 ± 6.2 years) and 7 women (mean age 59.5 ± 2.4 years). Clinical data of 12 healthy individuals were used as a control. According to statistic data, the average level of VEGF in bladder cancer patients urine was 246.55± 6.90 pg/ml which significantly exceeded this indicator in the control group (129.21± 7.60 pg/ml), the difference was statistically significant At bladder cancer diagnosis the sensitivity and specificity of the urinary level of TNF-α was low and amounted to 30% and 20%, respectively, and the level of TNF-β was even lower - 25% and 20%, respectively, which is not representative for the pathology under study.

Keywords

• carcinoma
• urinary bladder
• genotype
• growth factor
• necrosis factor
• polymorphism