Biomedical Engineering Advances (Dec 2021)
Detection of ketorolac drug using pencil graphite electrode
Abstract
The ketorolac (KEC) is a non-steroidal anti-inflammatory drug (NSAID) which is a water-soluble non-opioid analgesic drug that exhibits antipyretic properties that helps in the treatment concerned with pain. The reports were found on the adverse effect of overdosage of KEC on health which makes to develop the simple, sensitive, and economic electroanalytical method for the trace level detection of KEC. In the present study, pencil graphite was employed as the electrode (PGE) for the electrochemical detection of KEC. The effects of different electrochemical parameters viz., pH of electrolyte, scan rate, and concentration etc., on KEC were explored through cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The irreversible electrochemical reaction governed by the electrode process governed by the diffusion was attained by KEC at PGE. The linearity range was between 2.0 × 10−6 and 1.0 × 10−3 M, while the limit of detection was 4.59 × 10−7 M. The efficiency of the PGE was determined by analysing KEC in pharmaceutical drugs, and spiked real samples. The capability of the PGE towards the detection of KEC in presence of other chemicals was investigated by conducting an interference study. Hence, the proposed method can be applied for the determination of KEC in real biological and clinical samples.
