Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance

Abstract

Highlights Steady levels of estrogen are associated with changes in allergic inflammation. When E2 is maintained at a level comparable to the mid-follicular phase of ovulation mucus production and airway hyperreactivity are increased. Estrogen reduces eosinophils and ILC2 following allergen challenges. Neutrophils and CD19+ B cells were unaffected in the lung tissues by estrogen treatment.