Genotoxicity of mixture of imidacloprid, imazalil and tebuconazole

Nataliya A. Ilyushina; Olga V. Egorova; Gleb V. Masaltsev; Nataliya S. Averianova; Yulia A. Revazova; Valerii N. Rakitskii; Marina Goumenou; Alexander Vardavas; Polychronis Stivaktakis; Aristidis Tsatsakis

Toxicology Reports (Jan 2020)

Genotoxicity of mixture of imidacloprid, imazalil and tebuconazole

Nataliya A. Ilyushina,
Olga V. Egorova,
Gleb V. Masaltsev,
Nataliya S. Averianova,
Yulia A. Revazova,
Valerii N. Rakitskii,
Marina Goumenou,
Alexander Vardavas,
Polychronis Stivaktakis,
Aristidis Tsatsakis

Affiliations

Nataliya A. Ilyushina: The Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Region, 141014, Russian Federation; Corresponding author.
Olga V. Egorova: The Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Region, 141014, Russian Federation
Gleb V. Masaltsev: The Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Region, 141014, Russian Federation
Nataliya S. Averianova: The Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Region, 141014, Russian Federation
Yulia A. Revazova: The Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Region, 141014, Russian Federation
Valerii N. Rakitskii: The Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F. F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2 Semashko street, Mytishchi, Moscow Region, 141014, Russian Federation
Marina Goumenou: Centre of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece
Alexander Vardavas: Centre of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece
Polychronis Stivaktakis: Centre of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece
Aristidis Tsatsakis: Centre of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece

Journal volume & issue: Vol. 7
pp. 1090 – 1094

Abstract

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Genotoxicity of the mixture of generic pesticides imidacloprid + imazalil + tebuconazole in a ratio of 14.0/1.7/1.0 by weight was assessed using Ames test (Salmonella typhimurium) and micronucleus test in vivo on mammalian bone marrow erythrocytes (CD-1 mice) supporting the data creation for the Real Life Risk Simulation (RLRS) approach. This pesticides’ combination is used in the commercial formulation for seed treatment in advance of or immediately before sowing. Tested pesticides’ technical grade active ingredients (TGAIs) showed no evidence of genotoxicity upon separate treatments. In combination, the three pesticides demonstrated negative results in the Ames test but induced a statistically significant, dose-depended increase in MN-PCEs in mice bone marrow at doses lower than those used separately. The observed effect may be mediated by the synergistic action of the tested TGAIs, their metabolites or impurities.

Published in Toxicology Reports

ISSN: 2214-7500 (Online)
Publisher: Elsevier
Country of publisher: Ireland
LCC subjects: Medicine: Public aspects of medicine: Toxicology. Poisons
Website: http://www.journals.elsevier.com/toxicology-reports/

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