Inflammatory factors secreted from endothelial cells induced by high glucose impair human retinal pigment epithelial cells

Abstract

Diabetic retinopathy (DR) is a retinal disease that arises from impaired glucose tolerance and leads to retinal microvascular leakages. Recent studies have indicated that DR pathogenesis is linked to dysfunctional retinal pigment epithelial (RPE) cells.

Keywords

• diabetic retinopathy
• ecs injury
• inflammatory cytokines
• oxidative stress
• arpe-19 dysfunction
• the nf-κb pathway