Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease
Heeyoung Kang,
Hyun Joo Shin,
Hyeong Seok An,
Zhen Jin,
Jong Youl Lee,
Jaewoong Lee,
Kyung Eun Kim,
Eun Ae Jeong,
Kyu Yeong Choi,
Catriona McLean,
Kun Ho Lee,
Soo Kyoung Kim,
Hae Ryong Lee,
Gu Seob Roh
Affiliations
Heeyoung Kang
Department of Neurology, College of Medicine, Gyeongsang National University Hospital, Gyeongsang National University, Jinju 52727, Korea
Hyun Joo Shin
Bio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
Hyeong Seok An
Bio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
Zhen Jin
University of Tennessee Health Science Center, Department of Anatomy and Neurobiology, Memphis, TN 38163, USA
Jong Youl Lee
Bio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
Jaewoong Lee
Bio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
Kyung Eun Kim
Bio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
Eun Ae Jeong
Bio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
Kyu Yeong Choi
Gwangju Alzheimer’s & Related Dementia Cohort Research Center, Chosun University, Gwangju 61452, Korea
Catriona McLean
Department of Pathology, The Alfred Hospital, Melbourne 3004, Australia
Kun Ho Lee
Gwangju Alzheimer’s & Related Dementia Cohort Research Center, Chosun University, Gwangju 61452, Korea
Soo Kyoung Kim
Department of Internal Medicine, College of Medicine, Gyeongsang National University Hospital, Gyeongsang National University, Jinju 52727, Korea
Hae Ryong Lee
Electronics and Telecommunications Research Institute, Daejeon 34129, Korea
Gu Seob Roh
Bio Anti-Aging Medical Research Center, Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea
Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer’s disease (AD) has been less studied. We investigated the role of LCN2 in human AD patients using a mouse model of AD. We created an AD mouse model by injecting amyloid-beta oligomer (AβO) into the hippocampus. In this model, animals exhibited impaired learning and memory. We found LCN2 upregulation in the human brain frontal lobe, as well as a positive correlation between white matter ischemic changes and serum LCN2. We also found increased astrocytic LCN2, microglia activation, iron accumulation, and blood–brain barrier disruption in AβO-treated hippocampi. These findings suggest that LCN2 is involved in a variety of amyloid toxicity mechanisms, especially neuroinflammation and oxidative stress.
