Nature Communications (Aug 2018)

Network enhancement as a general method to denoise weighted biological networks

  • Bo Wang,
  • Armin Pourshafeie,
  • Marinka Zitnik,
  • Junjie Zhu,
  • Carlos D. Bustamante,
  • Serafim Batzoglou,
  • Jure Leskovec

DOI
https://doi.org/10.1038/s41467-018-05469-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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Technical noise in experiments is unavoidable, but it introduces inaccuracies into the biological networks we infer from the data. Here, the authors introduce a diffusion-based method for denoising undirected, weighted networks, and show that it improves the performances of downstream analyses.