cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases

Philipp Spitzer; Hans Wolfgang Klafki; Kaj Blennow; Luc Buée; Hermann Esselmann; Sanna-Kaisa Herruka; Connie Jimenez; Peter Klivenyi; Piotr Lewczuk; Juan Manuel Maler; Katrin Markus; Helmut E. Meyer; Chris Morris; Thorsten Müller; Markus Otto; Lucilla Parnetti; Hilkka Soininen; Susanna Schraen; Charlotte Teunissen; Laszlo Vecsei; Henrik Zetterberg; Jens Wiltfang

doi:10.4061/2010/548145

International Journal of Alzheimer's Disease (Jan 2010)

cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases

Philipp Spitzer,
Hans Wolfgang Klafki,
Kaj Blennow,
Luc Buée,
Hermann Esselmann,
Sanna-Kaisa Herruka,
Connie Jimenez,
Peter Klivenyi,
Piotr Lewczuk,
Juan Manuel Maler,
Katrin Markus,
Helmut E. Meyer,
Chris Morris,
Thorsten Müller,
Markus Otto,
Lucilla Parnetti,
Hilkka Soininen,
Susanna Schraen,
Charlotte Teunissen,
Laszlo Vecsei,
Henrik Zetterberg,
Jens Wiltfang

Affiliations

Philipp Spitzer: Laboratory for Molecular Neurobiology, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, LVR-Klinikum Essen, Virchowstraße 174, 45147 Essen, Germany
Hans Wolfgang Klafki: Laboratory for Molecular Neurobiology, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, LVR-Klinikum Essen, Virchowstraße 174, 45147 Essen, Germany
Kaj Blennow: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 431 80 Mölndal, Sweden
Luc Buée: Inserm U837, 1 Place de Verdun, 59045 Lille, France
Hermann Esselmann: Laboratory for Molecular Neurobiology, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, LVR-Klinikum Essen, Virchowstraße 174, 45147 Essen, Germany
Sanna-Kaisa Herruka: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Ylipistonranta 1C, 70211 Kuopio, Finland
Connie Jimenez: OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Peter Klivenyi: Department of Neurology, University of Szeged, P.O. Box 427, 6701 Szeged, Hungary
Piotr Lewczuk: Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
Juan Manuel Maler: Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
Katrin Markus: Functional Proteomics, Medizinisches Proteom-Center, Ruhr-University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
Helmut E. Meyer: Medical Proteomics/Bioanalytics, Medizinisches Proteom-Center, Ruhr-University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
Chris Morris: Medical Toxicology Centre, Institute for Ageing and Health, Institute of Neurosciences, University of Newcastle, Wolfson Unit, Claremont Place, Newcastle upon Tyne NE2 4AA, UK
Thorsten Müller: Functional Proteomics, Medizinisches Proteom-Center, Ruhr-University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
Markus Otto: Department of Neurology, University of Ulm, Steinhövelstraße 1, 89075 Ulm, Germany
Lucilla Parnetti: Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, 06156 Perugia, Italy
Hilkka Soininen: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Ylipistonranta 1C, 70211 Kuopio, Finland
Susanna Schraen: Inserm U837, 1 Place de Verdun, 59045 Lille, France
Charlotte Teunissen: Department of Clinical Chemistry, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
Laszlo Vecsei: Department of Neurology, University of Szeged, P.O. Box 427, 6701 Szeged, Hungary
Henrik Zetterberg: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 431 80 Mölndal, Sweden
Jens Wiltfang: Laboratory for Molecular Neurobiology, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, LVR-Klinikum Essen, Virchowstraße 174, 45147 Essen, Germany

DOI: https://doi.org/10.4061/2010/548145
Journal volume & issue: Vol. 2010

Abstract

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“clinical NEUroPROteomics of neurodegenerative diseases” (cNEUPRO) is a Specific Targeted Research Project (STREP) within the sixth framework program of the European Commission dedicated to the search for novel biomarker candidates for Alzheimer's disease and other neurodegenerative diseases. The ultimate goal of cNEUPRO is to identify one or more valid biomarker(s) in blood and CSF applicable to support the early and differential diagnosis of dementia disorders. The consortium covers all steps required for the discovery of novel biomarker candidates such as acquisition of high quality CSF and blood samples from relevant patient groups and controls, analysis of body fluids by various methods, and finally assay development and assay validation. Here we report the standardized procedures for diagnosis and preanalytical sample-handling within the project, as well as the status of the ongoing research activities and some first results.

Published in International Journal of Alzheimer's Disease

ISSN: 2090-8024 (Print); 2090-0252 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry; Medicine: Internal medicine: Special situations and conditions: Geriatrics
Website: https://www.hindawi.com/journals/ijad/

About the journal