Nature Communications (Oct 2022)
Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts
- Allen C. T. Teng,
- Liyang Gu,
- Michelle Di Paola,
- Robert Lakin,
- Zachary J. Williams,
- Aaron Au,
- Wenliang Chen,
- Neal I. Callaghan,
- Farigol Hakem Zadeh,
- Yu-Qing Zhou,
- Meena Fatah,
- Diptendu Chatterjee,
- L. Jane Jourdan,
- Jack Liu,
- Craig A. Simmons,
- Thomas Kislinger,
- Christopher M. Yip,
- Peter H. Backx,
- Robert G. Gourdie,
- Robert M. Hamilton,
- Anthony O. Gramolini
Affiliations
- Allen C. T. Teng
- Department of Physiology, Temerty Faculty of Medicine, University of Toronto
- Liyang Gu
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Michelle Di Paola
- Department of Physiology, Temerty Faculty of Medicine, University of Toronto
- Robert Lakin
- Department of Biology, York University
- Zachary J. Williams
- The Center for Heart and Reparative Medicine, Fralin Biomedical Research Institute at Virginia Tech. Carilion
- Aaron Au
- Institute of Biomedical Engineering, Faculty of Applied Science and Engineering, University of Toronto
- Wenliang Chen
- Department of Biology, York University
- Neal I. Callaghan
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Farigol Hakem Zadeh
- Department of Physiology, Temerty Faculty of Medicine, University of Toronto
- Yu-Qing Zhou
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Meena Fatah
- The Labatt Family Heart Centre (Dept. of Pediatrics) and Translational Medicine, The Hospital for Sick Children & Research Institute, University of Toronto
- Diptendu Chatterjee
- The Labatt Family Heart Centre (Dept. of Pediatrics) and Translational Medicine, The Hospital for Sick Children & Research Institute, University of Toronto
- L. Jane Jourdan
- The Center for Heart and Reparative Medicine, Fralin Biomedical Research Institute at Virginia Tech. Carilion
- Jack Liu
- Department of Physiology, Temerty Faculty of Medicine, University of Toronto
- Craig A. Simmons
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Thomas Kislinger
- Princess Margaret Cancer Centre, University Health Network
- Christopher M. Yip
- Institute of Biomedical Engineering, Faculty of Applied Science and Engineering, University of Toronto
- Peter H. Backx
- Department of Biology, York University
- Robert G. Gourdie
- The Center for Heart and Reparative Medicine, Fralin Biomedical Research Institute at Virginia Tech. Carilion
- Robert M. Hamilton
- The Labatt Family Heart Centre (Dept. of Pediatrics) and Translational Medicine, The Hospital for Sick Children & Research Institute, University of Toronto
- Anthony O. Gramolini
- Department of Physiology, Temerty Faculty of Medicine, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-022-33303-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrophysiology and cardiomyopathy in mice.
