A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

Guodong Li; Chung-Nga Ko; Dan Li; Chao Yang; Wanhe Wang; Guan-Jun Yang; Carmelo Di Primo; Vincent Kam Wai Wong; Yaozu Xiang; Ligen Lin; Dik-Lung Ma; Chung-Hang Leung

doi:10.1038/s41467-021-23448-7

Nature Communications (Jun 2021)

A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

Guodong Li,
Chung-Nga Ko,
Dan Li,
Chao Yang,
Wanhe Wang,
Guan-Jun Yang,
Carmelo Di Primo,
Vincent Kam Wai Wong,
Yaozu Xiang,
Ligen Lin,
Dik-Lung Ma,
Chung-Hang Leung

Affiliations

Guodong Li: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
Chung-Nga Ko: Department of Chemistry, Hong Kong Baptist University
Dan Li: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
Chao Yang: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
Wanhe Wang: Department of Chemistry, Hong Kong Baptist University
Guan-Jun Yang: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
Carmelo Di Primo: Laboratoire ARNA, University of Bordeaux
Vincent Kam Wai Wong: State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
Yaozu Xiang: Shanghai East Hospital of Tongji University, School of Life Sciences and Technology, Tongji University
Ligen Lin: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
Dik-Lung Ma: Department of Chemistry, Hong Kong Baptist University
Chung-Hang Leung: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau

DOI: https://doi.org/10.1038/s41467-021-23448-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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