Advance in topical biomaterials and mechanisms for the intervention of pressure injury
Yingying Pan,
Dejun Yang,
Min Zhou,
Yong Liu,
Jiandan Pan,
Yunlong Wu,
Lijiang Huang,
Huaqiong Li
Affiliations
Yingying Pan
School of Nursing, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
Dejun Yang
Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China; Corresponding author
Min Zhou
School of Nursing, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
Yong Liu
Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China; Joint Research Centre on Medicine, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China; Corresponding author
Jiandan Pan
The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
Yunlong Wu
Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China; School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian 361102, China
Lijiang Huang
Joint Research Centre on Medicine, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China
Huaqiong Li
Joint Research Centre on Medicine, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China; Corresponding author
Summary: Pressure injuries (PIs) are localized tissue damage resulting from prolonged compression or shear forces on the skin or underlying tissue, or both. Different stages of PIs share common features include intense oxidative stress, abnormal inflammatory response, cell death, and subdued tissue remodeling. Despite various clinical interventions, stage 1 or stage 2 PIs are hard to monitor for the changes of skin or identify from other disease, whereas stage 3 or stage 4 PIs are challenging to heal, painful, expensive to manage, and have a negative impact on quality of life. Here, we review the underlying pathogenesis and the current advances of biochemicals in PIs. We first discuss the crucial events involved in the pathogenesis of PIs and key biochemical pathways lead to wound delay. Then, we examine the recent progress of biomaterials-assisted wound prevention and healing and their prospects.
