Nature Communications (Jul 2016)

A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers

  • Anthony Ferrari,
  • Anne Vincent-Salomon,
  • Xavier Pivot,
  • Anne-Sophie Sertier,
  • Emilie Thomas,
  • Laurie Tonon,
  • Sandrine Boyault,
  • Eskeatnaf Mulugeta,
  • Isabelle Treilleux,
  • Gaëtan MacGrogan,
  • Laurent Arnould,
  • Janice Kielbassa,
  • Vincent Le Texier,
  • Hélène Blanché,
  • Jean-François Deleuze,
  • Jocelyne Jacquemier,
  • Marie-Christine Mathieu,
  • Frédérique Penault-Llorca,
  • Frédéric Bibeau,
  • Odette Mariani,
  • Cécile Mannina,
  • Jean-Yves Pierga,
  • Olivier Trédan,
  • Thomas Bachelot,
  • Hervé Bonnefoi,
  • Gilles Romieu,
  • Pierre Fumoleau,
  • Suzette Delaloge,
  • Maria Rios,
  • Jean-Marc Ferrero,
  • Carole Tarpin,
  • Catherine Bouteille,
  • Fabien Calvo,
  • Ivo Glynne Gut,
  • Marta Gut,
  • Sancha Martin,
  • Serena Nik-Zainal,
  • Michael R. Stratton,
  • Iris Pauporté,
  • Pierre Saintigny,
  • Daniel Birnbaum,
  • Alain Viari,
  • Gilles Thomas

DOI
https://doi.org/10.1038/ncomms12222
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

Read online

Breast cancer is separated into multiple subtypes based on the expression of HER2 and hormone receptors. Here, the authors report the whole genome sequence of 64 HER2 positive tumours and show that these can be further separated into four groups with different gene expression profiles and genomic features.