Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Amanda J Scopelliti; Josep Font; Robert J Vandenberg; Olga Boudker; Renae M Ryan

doi:10.1038/s41467-017-02444-w

Nature Communications (Jan 2018)

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Amanda J Scopelliti,
Josep Font,
Robert J Vandenberg,
Olga Boudker,
Renae M Ryan

Affiliations

Amanda J Scopelliti: Transporter Biology Group, Discipline of Pharmacology, Sydney Medical School, University of Sydney
Josep Font: Transporter Biology Group, Discipline of Pharmacology, Sydney Medical School, University of Sydney
Robert J Vandenberg: Transporter Biology Group, Discipline of Pharmacology, Sydney Medical School, University of Sydney
Olga Boudker: Department of Physiology and Biophysics, Weill Cornell Medicine
Renae M Ryan: Transporter Biology Group, Discipline of Pharmacology, Sydney Medical School, University of Sydney

DOI: https://doi.org/10.1038/s41467-017-02444-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for conferring glutamine selectivity to ASCT2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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