Synthesis of dihydrofurans using nano-CuFe2O4@Chitosan

Abstract

An efficient multi-component synthesis of dihydrofurans is described by a one-pot condensation reaction of 2,4′-dibromoacetophenone, aromatic aldehydes and dimedone using nano-CuFe2O4@Chitosan under reflux conditions in ethanol. The key advantages of this process are the diastereoselective synthesis, low catalyst loading, reusability of the catalyst, excellent yields, short reaction times, simple workup and environmentally benign. Keywords: Nano-CuFe2O4@Chitosan, Nanocatalyst, Dihydrofurans, Diastereoselective synthesis, One-pot