Nature Communications (Jul 2019)
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
- Tongde Du,
- Hongchang Li,
- Yongsheng Fan,
- Lin Yuan,
- Xiaodan Guo,
- Qiong Zhu,
- Yuying Yao,
- Xin Li,
- Chunlei Liu,
- Xinhe Yu,
- Zhaofei Liu,
- Chun-Ping Cui,
- Chuanchun Han,
- Lingqiang Zhang
Affiliations
- Tongde Du
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Hongchang Li
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Yongsheng Fan
- Institute of Cancer Stem Cell, Dalian Medical University
- Lin Yuan
- Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center
- Xiaodan Guo
- Institute of Cancer Stem Cell, Dalian Medical University
- Qiong Zhu
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Yuying Yao
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Xin Li
- Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, Core Laboratory of Translational Medicine, Chinese PLA General Hospital
- Chunlei Liu
- Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, Core Laboratory of Translational Medicine, Chinese PLA General Hospital
- Xinhe Yu
- Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center
- Zhaofei Liu
- Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center
- Chun-Ping Cui
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Chuanchun Han
- Institute of Cancer Stem Cell, Dalian Medical University
- Lingqiang Zhang
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- DOI
- https://doi.org/10.1038/s41467-019-10824-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The deubiquitylase OTUD3 can function as a tumour-suppressor by stabilizing PTEN. Here, the authors show that OTUD3 also has an oncogenic role in lung cancer by stabilizing the glucose-regulated protein GRP78.
