The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis

Qian Gao; Junfeng Zhang; Xiumei Wang; Ying Liu; Rongqiao He; Xingfeng Liu; Fei Wang; Jing Feng; Dongling Yang; Zhaoqing Wang; Anming Meng; Xiyun Yan

doi:10.1038/ncomms15279

Nature Communications (Jun 2017)

The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis

Qian Gao,
Junfeng Zhang,
Xiumei Wang,
Ying Liu,
Rongqiao He,
Xingfeng Liu,
Fei Wang,
Jing Feng,
Dongling Yang,
Zhaoqing Wang,
Anming Meng,
Xiyun Yan

Affiliations

Qian Gao: Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences
Junfeng Zhang: State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University
Xiumei Wang: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Ying Liu: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Rongqiao He: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Xingfeng Liu: State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University
Fei Wang: Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences
Jing Feng: Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences
Dongling Yang: Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences
Zhaoqing Wang: Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences
Anming Meng: State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University
Xiyun Yan: Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/ncomms15279
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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It is unclear if there is an interaction between apical-basal (AB) polarity and planar cell polarity (PCP) pathways during morphogenesis. Here, the authors define a role for the melanoma cell adhesion molecule (MCAM), known to regulate PCP, in AB polarity via FGF signallingin vitroand in zebrafish.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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