General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones

Abstract

Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran derivatives 3a-3af.

Keywords

• pyrano[4
• 3-b]pyran
• pyrano[3
• 2-c]pyridine
• arylmethylene malononitrile
• arylmethylene cyanoacetate
• Michael addition