LONG-TERM OUTCOMES IN BREAST CANCER PATIENTS AFTER COMPLEX TREATMENT WITH ADJUVANT RADIATION THERAPY

Abstract

The study included 103 patients with stage T1–3N0–3M0 breast cancer who received multimodality treatment including neo- and adjuvant chemotherapy according to CMF and CAF schedules, hormonal therapy, radical mastectomy and adjuvant radiation therapy. All patients were divided into two groups depending on the volume of postoperative radiation therapy. Group I patients (n=48) received 40–44 Gy external radiation therapy to the areas of potential regional spread. Group II patients (n-55) additionally received radiation therapy delivered to postoperative scar area at a total dose of 38–44 isoGy. The comparative analysis of long-term results showed a significant decrease in the rate of local recurrences and increase in the 5-year recurrence-free and overall survival rates in the group of breast cancer patients who received adjuvant radiation therapy to the areas of potential regional spread and postoperative scar. In order to plan adequate radiotherapyand to minimize local radiation-induced reactions, it is necessary to consider clinical and morphological prognostic factors.

Keywords

• рак молочной железы
• адъювантная лучевая терапия
• комплексное лечение