Calpain and oral cancer – A novel approach to detect cancer cell invasion

Abstract

Calpain is a Ca2+ dependent non-lysosomal cytosolic and mitochondrial cysteine protease found in tissue and organ specific manner in human being and in other mammals. It is observed to be an initiator for cancer cell propagation and invasion in Oral Squamous Cell Carcinoma (OSCC) and also a regulator of apoptosis. A concised review on this novice molecule is re-explored based on previous and ongoing studies in the following article.

Keywords

• apoptosis
• calpain
• cell invasion
• oral squamous cell carcinoma