Feasibility Study of <i>Lactobacillus Plantarum 299v</i> Probiotic Supplementation in an Urban Academic Facility among Diverse Pregnant Individuals
Nefertiti OjiNjideka Hemphill,
Lacey Pezley,
Alana Steffen,
Gloria Elam,
Michelle A. Kominiarek,
Angela Odoms-Young,
Nicollette Kessee,
Alyshia Hamm,
Lisa Tussing-Humphreys,
Mary Dawn Koenig
Affiliations
Nefertiti OjiNjideka Hemphill
Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W. Taylor St., Chicago, IL 60612, USA
Lacey Pezley
Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W. Taylor St., Chicago, IL 60612, USA
Alana Steffen
Department of Population Health Nursing Science, College of Nursing, University of Illinois at Chicago, 845 S. Damen Ave, Chicago, IL 60612, USA
Gloria Elam
Department of Obstetrics and Gynecology, College of Medicine, University of Illinois at Chicago, 820 S. Wood St., Chicago, IL 60612, USA
Michelle A. Kominiarek
Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 250 W. Superior St., Chicago, IL 60611, USA
Angela Odoms-Young
Division of Nutritional Sciences, College of Human Ecology, Cornell University, 116 Reservoir Ave, Ithaca, NY 14853, USA
Nicollette Kessee
Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W. Taylor St., Chicago, IL 60612, USA
Alyshia Hamm
Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W. Taylor St., Chicago, IL 60612, USA
Lisa Tussing-Humphreys
Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W. Taylor St., Chicago, IL 60612, USA
Mary Dawn Koenig
Department of Human Development Nursing Science, College of Nursing, University of Illinois at Chicago, 845 S. Damen Ave, Chicago, IL 60612, USA
(1) Background: Despite iron intake recommendations, over a quarter of pregnant individuals have iron deficiency. Lactobacillus plantarum 299v enhances iron absorption in non-pregnant populations and may have positive effects in pregnancy among those with sufficient iron stores; however, no studies have evaluated the effect of Lp299v on maternal and neonatal iron status among individuals at risk for iron deficiency anemia in pregnancy. Thus, this study aims to assess the feasibility and preliminary efficacy of daily oral Lp299v maternal supplementation among diverse pregnant individuals. (2) Methods: In this double-blind placebo-controlled randomized supplementation feasibility study, participants were randomized to probiotic Lp299v + prenatal vitamin with iron or placebo + prenatal vitamin with iron from 15–20 weeks of gestation through delivery. (3) Results: Of the 20 enrolled and randomized participants, 58% (7/12) from the Lp299v group and 75% (6/8) from the placebo group were retained. Adherence to supplementation was 72% for Lp299v/placebo and 73% for the prenatal vitamin. A slower decline in maternal hematological and iron parameters across pregnancy was observed in the Lp299v group compared to placebo. (4) Conclusions: Lp299v may be a tolerable therapy during pregnancy and has the potential to affect maternal and neonatal hematological and iron status.