Sleep disorder in Angelman syndrome: causes, mechanisms and methods of correction. Literature review

Abstract

Sleep disorder is one of the prominent manifestations of Angelman syndrome. The exact causes are unknown and methods of correction are difficult. The literature review is devoted to studies of the pathogenesis of sleep disorders in Angelman syndrome (the effects of gene function in 15q11–q13 deletion, findings in polysomnography, video-EEG sleep monitoring, laboratory data), on the basis of which recommendations for the correction of dyssomnia, including methods of behavioral therapy, are given.

Keywords

• angelman syndrome
• ube3a gene
• sleep disorders
• dyssomnia
• epilepsy
• video-eeg monitoring
• polysomnography
• notched-delta activity (notched-delta)
• methods of behavioral therapy