International Medical Case Reports Journal (May 2021)
Liver Transplantation in a Child with Kartagener Syndrome: A Case Report
Abstract
Tumay Uludag Yanaral,1 Pelin Karaaslan,1 Emine Uzunoglu,1 Yunus Oktay Atalay,1 Joseph Drew Tobias2 1Department of Anesthesiology and Reanimation, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey; 2Departments of Anesthesiology & Pain Medicine, Nationwide Children’s Hospital & The Ohio State University, Columbus, OH, USACorrespondence: Tumay Uludag YanaralMedipol Mega Hastanesi, Anestezi Klinigi, Goztepe Mah. No. 4, 34214, Bagcilar, Istanbul, TurkeyTel +90 505 242 2100Fax +90 212 460 7070Email [email protected]: Kartagener syndrome (KS) is a rare genetic disorder consisting of the triad of situs inversus, chronic sinusitis, and bronchiectasis. Although there are previous reports regarding the anaesthetic considerations in KS, none have included liver transplantation.Case Presentation: An 11-year-old boy with a diagnosis of KS underwent liver transplantation due to extrahepatic biliary atresia. Previous diagnostic imaging confirmed situs inversus and the absence of an inferior vena cava. The patient’s peak airway pressure intermittently increased intraoperatively from 15 to 30 cm H2O due to increased pulmonary secretions, which required frequent suctioning of the endotracheal tube. Intraoperative volume resuscitation included 200 mL of 5% albumin, 5 units of erythrocyte suspension and 3 units of fresh frozen plasma. Intermittently, a norepinephrine infusion was required to maintain the MAP. Coagulation function was monitoring using the thromboelastogram to guide the use of blood products including fresh frozen plasma. At the end of the surgery, the patient was transferred to the intensive care unit. He was discharged from the intensive care unit on postoperative day 5, and from the hospital on postoperative day 28. He continues to do well with normal liver function 23 months after surgery.Conclusion: Despite the risk of pulmonary related to airway secretions and exacerbation of hemodynamic instability related to anatomical variations in the inferior vena cava anatomy, KS patients can be safely anesthetized with careful planning and attention of the disease process, even for complex surgical procedures such as liver transplantation.Keywords: anesthesia, child, Kartagener syndrome, liver transplantation, situs inversus
